In studying my own software usage with Apple Activity Monitor, the only business-critical non-x86 binaries on my iMac are Microsoft’s Office 2004 suite and Adobe’s Creative Suite CS2 . Those continue to run through Rosetta, Apple’s translation layer. With Rosetta, applications consume huge amounts of virtual memory, and bog down to poor garbage collection.
Considering that Apple’s move to Intel processors was only announced in June 2005, and that the first Intel hardware began shipping in January 2006, this is a lightning fast transition.
Apple’s Safari browser is not as successful. Many Web applications (including the blog-writing system on blogger.com) don’t work correctly under Safari, and require Firefox to run on the Mac. This is particularly true of AJAX applications, and those which rely upon Flash. Safari’s RSS capabilities are dreadful; I use NewsGator’s NetNewsWire. I hope that Apple does a better job with Leopard.